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dc.contributor.authorAebi-Popp, Karoline-
dc.contributor.authorBailey, Heather-
dc.contributor.authorMalyuta, Ruslan-
dc.contributor.authorVolokha, Alla-
dc.contributor.authorThorne, Claire-
dc.contributor.editorBMC Pregnancy and Childbirth (2016) 16:94 DOI 10.1186/s12884-016-0887-y-
dc.date.accessioned2016-07-09T20:31:40Z-
dc.date.available2016-07-09T20:31:40Z-
dc.date.issued2016-
dc.identifier.urihttp://lib.inmeds.com.ua/jspui/handle/lib/526-
dc.description.abstractBackground: Over 3500 HIV-positive women give birth annually in Ukraine, a setting with high prevalence of sexually transmitted infections. Herpes simplex virus Type 2 (HSV-2) co-infection may increase HIV mother-to-child transmission (MTCT) risk. We explored factors associated with HSV-2 seropositivity among HIV-positive women in Ukraine, and its impact on HIV MTCT. Methods: Data on 1513 HIV-positive women enrolled in the Ukraine European Collaborative Study from 2007 to 2012 were analysed. Poisson and logistic regression models respectively were fit to investigate factors associated with HSV-2 seropositivity and HIV MTCT. Results: Median maternal age was 27 years (IQR 24–31), 53 % (796/1513) had been diagnosed with HIV during their most recent pregnancy and 20 % had a history of injecting drugs. Median antenatal CD4 count was 430 cells/mm3 (IQR 290–580). Ninety-six percent had received antiretroviral therapy antenatally. HSV-2 seroprevalence was 68 % (1026/1513). In adjusted analyses, factors associated with HSV-2 antibodies were history of pregnancy termination (APR 1.30 (95 % CI 1.18–1.43) for ≥2 vs. 0), having an HIV-positive partner (APR 1.15 (95 % CI 1.05–1.26) vs partner’s HIV status unknown) and HCV seropositivity (APR 1.23 (95 % CI 1.13–1.35)). The overall HIV MTCT rate was 2.80 % (95 % CI 1.98–3.84); no increased HIV MTCT risk was detected among HSV-2 seropositive women after adjusting for known risk factors (AOR 1.43 (95 % CI 0.54–3.77). Conclusion: No increased risk of HIV MTCT was detected among the 68 % of HIV-positive women with antibodies to HSV-2, in this population with an overall HIV MTCT rate of 2.8 %. Markers of ongoing sexual risk among HIV-positive HSV-2 seronegative women indicate the importance of interventions to prevent primary HSV-2 infection during pregnancy in this high-risk group.uk_UK
dc.language.isoenuk_UK
dc.subjectHIV, Pregnancy, Herpes simplex virus, Mother to child transmissionuk_UK
dc.titleHigh prevalence of herpes simplex virus (HSV)- type 2 co-infection among HIVpositive women in Ukraine, but no increased HIV mother-to-child transmission riskuk_UK
dc.typeArticleuk_UK
Розташовується у зібраннях:Кафедра дитячих інфекційних хвороб та дитячої імунології

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