1. Репозитарій НУОЗ України імені П. Л. Шупика
  2. Український державний інститут репродуктології
  3. Кафедра медичної та лабораторної генетики
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Поле DCЗначенняМова
dc.contributor.authorФіщук, Л-
dc.contributor.authorРозсоха, З.-
dc.contributor.authorЛобанова, О.-
dc.contributor.authorЧешук, В.-
dc.contributor.authorВерещако, Р.-
dc.contributor.authorВершигора, В.-
dc.contributor.authorМедведєва, Н.-
dc.contributor.authorДубицька, О.-
dc.contributor.authorГоровенко, Н.-
dc.date.accessioned2024-11-12T13:43:57Z-
dc.date.available2024-11-12T13:43:57Z-
dc.date.issued2024-
dc.identifier.citationhttps://doi.org/10.3233/CBM-230458uk_UK
dc.identifier.issnISSN 15740153, (Print) 18758592(Online)-
dc.identifier.urihttp://lib.inmeds.com.ua:8080/jspui/handle/lib/4997-
dc.descriptionBreast cancer is an important medical and social problem. Breast cancer in women reduces life ex- pectancy and worsens its quality, starting from theworking age. It is known that Central Asian and Eastern European countries have higher mortality rates from breast and cervical cancer and later diagnosis com- pared to countries in other parts of the WHO European Region [1]. In particular, in Ukraine, according to the National Cancer Registry of Ukraine, breast cancer is the leading cause of morbidity and death from malig- nant tumours among women [2]. Thus, in 2021, 14036 new cases of this disease were registered in women and 4732 deaths (the number of cases does not includethe data from the Donetsk and Luhansk regions, the Autonomous Republic of Crimea and the city of Sev- astopol). Only 31.9% of cases were detected during pre- ventive check-ups and 47.3% of newly diagnosed cases had stage II disease. At the same time, the incidence of breast cancer among women in Ukraine has been steadily increasing every year over the past decade. There are population differences in the frequencies of pathogenic variants of the BRCA1 and BRCA2 genes and epigenetic events, which may be associated with different incidence rates and features of breast can- cer [3,4,5]. Ecology, climate, residence and lifestyle may be other factors that may also have population dif- ferences [4,6]. In addition, it is worth remembering that even hereditary cancer can be polygenic in nature, with varying degrees of contribution from modifier genes.uk_UK
dc.description.abstractBACKGROUND: The BRCA2 gene is an important tumour suppressor in breast cancer, and alterations in BRCA2 may lead to cancer progression. The aim of the study was to investigate the association of hypermethylation of the BRCA2 gene promoter and its co-hypermethylation with the BRCA1 gene promoter with the development and course of breast cancer in women. METHODS: This study included 74 women with breast cancer (tumour tissue samples and peripheral blood) and 62 women without oncological pathology (peripheral blood) – control group. RESULTS: Hypermethylation of the BRCA2 gene was significantly more frequently detected in the tumour tissue of women with breast cancer compared to their peripheral blood and peripheral blood of control subjects (p = 0.0006 and p = 0.00001, respectively). Hypermethylation of BRCA2 was more frequently detected in patients with breast cancer over the age of 50 and in patients with higher Ki67 expression levels (p = 0.045 and p = 0.045, respectively). There was a high frequency of unmethylated BRCA1 and BRCA2 gene combination in women of the control group compared to women with breast cancer, both in blood samples and tumour tissue samples (p = 0.014 and p = 0.00001, respectively). CONCLUSION: Our study confirms the hypothesis that BRCA2 hypermethylation plays an important role in the pathogenesis of breast cancer and the importance of assessing its co-hypermethylation with BRCA1 in predicting the course of the disease.uk_UK
dc.language.isoenuk_UK
dc.publisherCancer Biomarkers.uk_UK
dc.relation.ispartofseriesVol. 40.;P. 275-283.-
dc.subjectBreast canceruk_UK
dc.subjectBRCA2uk_UK
dc.subjectBRCA1uk_UK
dc.subjecthypermethylationuk_UK
dc.subjectgeneuk_UK
dc.titleHypermethylation of the BRCA2 gene promoter and its co-hypermethylation with the BRCA1 gene promoter in patients with breast canceruk_UK
dc.typeArticleuk_UK
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