Будь ласка, використовуйте цей ідентифікатор, щоб цитувати або посилатися на цей матеріал: http://lib.inmeds.com.ua:8080/jspui/handle/lib/4723
Повний запис метаданих
Поле DCЗначенняМова
dc.contributor.authorФіщук, Л.Є.-
dc.contributor.authorЛобанова, О.Є.-
dc.contributor.authorРоссоха, З.І.-
dc.contributor.authorЧешук, В.-
dc.contributor.authorВерещако, Р.-
dc.contributor.authorВагін, Ю.-
dc.contributor.authorКашуба, В-
dc.contributor.authorВершигора, В.О.-
dc.contributor.authorПопова, О.Ф.-
dc.contributor.authorЛевкович, Н.М.-
dc.contributor.authorЗемлянська, О.-
dc.contributor.authorЄвсеєнкова, О.Г.-
dc.contributor.authorПодольська, С.В.-
dc.contributor.authorГоровенко, Н.Г.-
dc.date.accessioned2023-11-17T12:03:17Z-
dc.date.available2023-11-17T12:03:17Z-
dc.date.issued2023-
dc.identifier.citationhttps://doi.org/10.15407/exp-oncology.2023.02.161uk_UK
dc.identifier.issnISSN: 2312-8852-
dc.identifier.urihttp://lib.inmeds.com.ua:8080/jspui/handle/lib/4723-
dc.descriptionMaterials and Methods. The study involved 210 patients with newly diag-nosed BC. The most common germline pathogenic variants of the BRCA1 (185delAG, 5382insC, 4153delA, T300G) and BRCA2 (6174delT) genes were identified in the peripheral blood. A subgroup of 14 patients without progenitor pathological variants of the BRCA1 and BRCA2 genes and with a family history of cancer was randomly selected. For them, BRCA1 gene sequencing by Sanger and hypermethylation of the BRCA1 gene promoter region were analyzed. Results. The following frequencies of BRCA1 mutations were determined in the general group: 5382insC – 8.6%, 4153delA – 0.5%, T300G – 0.5%. The analysis of the BRCA1 gene by Sanger sequencing revealed 11 BRCA1 gene variants in 10 out of 14 BC patients. All of them, according to the currently available data, were defined as “benign” and not clinically relevant. The frequency of the detection of hypermethylation of the BRCA1 gene promoter region in the randomly selected group of patients was 14.3%. Conclusions. In BC patients, not only common mutations but also the methylation status of the BRCA1 gene promoter region in the peripheral blood should be determined. The whole-genome sequencing of the BRCA1 gene may be the last step in determining the genetic characteristics of BC patients carried out to optimize the treatment and improve survival thanks to the higher prevalence of the progenitor mutations and hypermethylation of the BRCA1 gene promoter.uk_UK
dc.description.abstractCurrently, there is a great interest in the genetic testing of BRCA1 and BRCA2 due to the fact that for patients with breast cancer (BC) with pathogenic variants of these genes, the use of the PARP inhibitors could be also provided in addition to implemented treatment protocols. The aim of this study was to characterize the molecular genetic structure of the BRCA1 gene in BC patients without progenitor germline mutations taking into account the methylation state of the promoter regionuk_UK
dc.language.isoenuk_UK
dc.publisherExperimental Oncologyuk_UK
dc.relation.ispartofseriesVol. 45, no. 2.;P. 25-33.-
dc.subjectBRCA1uk_UK
dc.subjectBRCA2uk_UK
dc.subjecthypermethylationuk_UK
dc.subject5382insCuk_UK
dc.subjectbreast canceruk_UK
dc.subjectsequencinguk_UK
dc.titleClinical significance of BRCA1 gene sequencing and its promoter methylation testing in the search strategy for therapeutic targets in breast cancer treatmentuk_UK
dc.typeArticleuk_UK
Розташовується у зібраннях:Кафедра медичної та лабораторної генетики

Файли цього матеріалу:
Файл Опис РозмірФормат 
Clinical significance of BRCA1 gene sequencing and its promoter methylation testing in the search strategy for therapeutic targets in breast cancer treatment.docxОсновна стаття518.28 kBMicrosoft Word XMLПереглянути/Відкрити


Усі матеріали в архіві електронних ресурсів захищені авторським правом, всі права збережені.