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Повний запис метаданих
Поле DC | Значення | Мова |
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dc.contributor.author | Россоха, З.І. | - |
dc.contributor.author | Фіщук, Л.Є | - |
dc.contributor.author | Лобанова, О.Є. | - |
dc.contributor.author | Медведєва, Н.Л. | - |
dc.contributor.author | Чешук, В. | - |
dc.contributor.author | Вершигора, В.О. | - |
dc.contributor.author | Верещако, Р. | - |
dc.contributor.author | Горовенко, Н.Г. | - |
dc.date.accessioned | 2023-11-17T11:18:56Z | - |
dc.date.available | 2023-11-17T11:18:56Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | https://doi.org/10.1007/s00432-023-05034-0 | uk_UK |
dc.identifier.issn | ISSN : 0171-5216 Linking ISSN (ISSN-L): 0171-5216 | - |
dc.identifier.uri | http://lib.inmeds.com.ua:8080/jspui/handle/lib/4719 | - |
dc.description | A significantly increased frequency of the hypermethylation of the RUNX3 gene promoter region and its cohypermethylation with the BRCA1 gene promoter region was found in tumor tissue and blood samples from patients with breast cancer, in contrast to the control group. The identified differences indicate the importance of further investigations of suppressor genes cohypermethylation in patients with breast cancer. Further large-scale studies are needed to find out whether the detected hypermethylation and cohypermethylation of the RUNX3 gene promoter region will have an impact on the treatment strategy in patients. | uk_UK |
dc.description.abstract | The aim of this study was to assess the clinical significance of RUNX3 gene hypermethylation in the pathogenetic mechanisms of breast cancer in women, taking into account its cohypermethylation with the BRCA1 gene.This study included 74 women with newly diagnosed breast cancer (samples from female primary breast carcinomas and paired peripheral blood samples) and 62 women without oncological pathology—control group (peripheral blood samples). Epigenetic testing for hypermethylation status studying was performed in all samples on freshly collected material with the addition of a preservative before the storage and DNA isolation. | uk_UK |
dc.language.iso | en | uk_UK |
dc.publisher | Journal of Cancer Research and Clinical Oncology | uk_UK |
dc.relation.ispartofseries | volume 149;pages11919–11927 | - |
dc.subject | RUNX3 gene hypermethylation | uk_UK |
dc.subject | breast cancer | uk_UK |
dc.subject | Epigenetic testing | uk_UK |
dc.subject | hypermethylation status | uk_UK |
dc.title | Clinical significance of determining the hypermethylation of the RUNX3 gene promoter and its cohypermethylation with the BRCA1 gene for patients with breast cancer | uk_UK |
dc.type | Article | uk_UK |
Розташовується у зібраннях: | Кафедра медичної та лабораторної генетики |
Файли цього матеріалу:
Файл | Опис | Розмір | Формат | |
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Clinical significance of determining the hypermethylation of the RUNX3 gene promoter and its cohypermethylation with the BRCA1 gene for patients with breast cancer.docx | Основна стаття | 165.73 kB | Microsoft Word XML | Переглянути/Відкрити |
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