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dc.contributor.authorРоссоха, З.І.-
dc.contributor.authorФіщук, Л.Є-
dc.contributor.authorЛобанова, О.Є.-
dc.contributor.authorМедведєва, Н.Л.-
dc.contributor.authorЧешук, В.-
dc.contributor.authorВершигора, В.О.-
dc.contributor.authorВерещако, Р.-
dc.contributor.authorГоровенко, Н.Г.-
dc.date.accessioned2023-11-17T11:18:56Z-
dc.date.available2023-11-17T11:18:56Z-
dc.date.issued2023-
dc.identifier.citationhttps://doi.org/10.1007/s00432-023-05034-0uk_UK
dc.identifier.issnISSN : 0171-5216 Linking ISSN (ISSN-L): 0171-5216-
dc.identifier.urihttp://lib.inmeds.com.ua:8080/jspui/handle/lib/4719-
dc.descriptionA significantly increased frequency of the hypermethylation of the RUNX3 gene promoter region and its cohypermethylation with the BRCA1 gene promoter region was found in tumor tissue and blood samples from patients with breast cancer, in contrast to the control group. The identified differences indicate the importance of further investigations of suppressor genes cohypermethylation in patients with breast cancer. Further large-scale studies are needed to find out whether the detected hypermethylation and cohypermethylation of the RUNX3 gene promoter region will have an impact on the treatment strategy in patients.uk_UK
dc.description.abstractThe aim of this study was to assess the clinical significance of RUNX3 gene hypermethylation in the pathogenetic mechanisms of breast cancer in women, taking into account its cohypermethylation with the BRCA1 gene.This study included 74 women with newly diagnosed breast cancer (samples from female primary breast carcinomas and paired peripheral blood samples) and 62 women without oncological pathology—control group (peripheral blood samples). Epigenetic testing for hypermethylation status studying was performed in all samples on freshly collected material with the addition of a preservative before the storage and DNA isolation.uk_UK
dc.language.isoenuk_UK
dc.publisherJournal of Cancer Research and Clinical Oncologyuk_UK
dc.relation.ispartofseriesvolume 149;pages11919–11927-
dc.subjectRUNX3 gene hypermethylationuk_UK
dc.subjectbreast canceruk_UK
dc.subjectEpigenetic testinguk_UK
dc.subjecthypermethylation statusuk_UK
dc.titleClinical significance of determining the hypermethylation of the RUNX3 gene promoter and its cohypermethylation with the BRCA1 gene for patients with breast canceruk_UK
dc.typeArticleuk_UK
Розташовується у зібраннях:Кафедра медичної та лабораторної генетики

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