ANALYSIS OF ERYTHROCYTES’ PARAMETERS IN PATIENTS WITH VARYING DEGREES OF DIABETIC RETINOPATHY

Abstract

Morpho-functional parameters of erythrocytes determine their physiological capacity for gas exchange. In effective gas exchange causes tissue hypoxia and is one of the pathogenetic pathways for the development of diabetic retinopathy (DR). The purpose is to study the morpho-functional parameters of erythrocytes in patients with varying degrees of development of DR as an important factor in providing tissue respiration. Materials and methods. The parameters of hemogram were studied in patients with DR: 1 group (n = 36) with mild and moderate nonproliferative DR, 2 groups (n = 54) with moderate proliferative DR (DR), and 3 groups (n = 31) with advanced DR. Patients (n = 86) without diabetes and without retinal pathology who were matched for age and sex were examined made up the control group. The hemogram was obtain in the study of venous blood by means of a hematological analyzer (MicroCS, China). In the laboratory of clinical laboratory diagnostics of Bogomolets NMU. The results were analyze using the SPSS Statistics 23 (using Kruskal-Wallis, Scheffe or Dunn criteria). Results. The decrease in HGB and MCHC compared with the control group were find in all patients with DR. RBC and HTC differed from the control group only in the group with advanced DR. Indicators of erythrocytes anyzocytosis (MCV, RDW-CV) did not have a significant difference in patients with DR and control group. Conclusions. The obtained data provide the basis for the analysis of pathogenetic pathways of tissue hy poxia in patients with DR, and to develop recommendations for it elimination.