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Назва: | Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths |
Автори: | Bastard, Paul Gervais, Adrian Le Voyer, Tom Rosain, Jérémie Philippot, Quentin Manry, Jérémy Bousfiha, Ahmed A. Meyts, Isabelle Sallette, Jérome Бондаренко, А.В. Spaan, András N. Lifton, Richard P. Степановський, Ю.С. COVID Clinicians Волоха, А.П. COVID Human Genetic Effort Jouanguy, Emmanuelle Zhang, Qian Cobat, Aurélie Abel, Laurent Casanova, J.-L. |
Ключові слова: | COVID-19 інтерферон |
Дата публікації: | 2021 |
Видавництво: | American Association for the Advancement of Science |
Бібліографічний опис: | Bastard P. et al. Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths//Sci. Immunol. 2021; 6 : eabl4340 |
Серія/номер: | SCIENCE IMMUNOLOGY;Sci. Immunol. 2021; 6 : eabl4340 |
Короткий огляд (реферат): | Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/ml; in plasma diluted 1:10) of IFN- and/or IFN- are found in about 10% of patients with critical COVID-19 (coronavirus disease 2019) pneumonia but not in individuals with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiolog- ical, concentrations of IFN- and/or IFN- (100 pg/ml; in 1:10 dilutions of plasma) in 13.6% of 3595 patients with critical COVID-19, including 21% of 374 patients >80 years, and 6.5% of 522 patients with severe COVID-19. These antibodies are also detected in 18% of the 1124 deceased patients (aged 20 days to 99 years; mean: 70 years). Moreover, another 1.3% of patients with critical COVID-19 and 0.9% of the deceased patients have auto-Abs neu- tralizing high concentrations of IFN-. We also show, in a sample of 34,159 uninfected individuals from the gener- al population, that auto-Abs neutralizing high concentrations of IFN- and/or IFN- are present in 0.18% of individuals between 18 and 69 years, 1.1% between 70 and 79 years, and 3.4% >80 years. Moreover, the propor- tion of individuals carrying auto-Abs neutralizing lower concentrations is greater in a subsample of 10,778 unin- fected individuals: 1% of individuals <70 years, 2.3% between 70 and 80 years, and 6.3% >80 years. By contrast, auto-Abs neutralizing IFN- do not become more frequent with age. Auto-Abs neutralizing type I IFNs predate SARS-CoV-2 infection and sharply increase in prevalence after the age of 70 years. They account for about 20% of both critical COVID-19 cases in the over 80s and total fatal COVID-19 cases. |
URI (Уніфікований ідентифікатор ресурсу): | http://lib.inmeds.com.ua:8080/jspui/handle/lib/3750 |
Розташовується у зібраннях: | Кафедра дитячих інфекційних хвороб та дитячої імунології |
Файли цього матеріалу:
Файл | Опис | Розмір | Формат | |
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sciimmunol.abl4340.pdf | 4.45 MB | Adobe PDF | Переглянути/Відкрити |
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