Features of the course and treatment of low back pain in patients with reduced bone mineral density

Abstract

Ob jec tive. To in ves ti gate the fea tures of the course, clin i cal man i fes ta tions and the ef fect of symp tom atic slow anti-in flam ma tory drugs (SYSADOA) on the course of the dis ease in pa tients with low back pain and low bone min eral den sity. Ma te ri als and meth ods. The study in cluded 100 pa tients (60 women and 40 men) aged 34 to 80 years. Pa tients were divided into 3 groups de pend ing on the in dex of bone min eral den sity (BMD). Pe cu liar i ties of the course and ef fec tive ness of treat ment were as sessed us - ing ques tion naires VAS, Oswestry, Roland-Mor ris and McGill. Lev els of non spe cific in di - ca tors of in flam ma tion (ESR and CRP), cytokines (IL-1, IGF-1, NO), met a bolic in di ca tors (lipid, carbo hy drate, liver mark ers) were also stud ied. “SPSS Sta tis tics” soft ware was used for sta tis ti cal data pro cess ing. Re sults. The re search showed that patients with low bone min eral den sity had worse per - for mance results on the VAS, Oswestry, McGill and Roland-Mor ris ques tion naires com - pared to pa tients with nor mal BMD. In flam ma tory rates such as ESR, CRP, IL-1, NO, IGF-1 were also worse in pa tients with low bone min eral den sity. The dy nam ics of ques tion naires and in flam ma tory mark ers dur ing treat ment was better in pa tients with nor mal BMD. Con clu sions. Our study showed that pa tients with low bone min eral den sity had a more se vere course of low back pain: more in tense in flam ma tion, worse psy cho-emo tional state, phys i cal activ ity and quality of life com pared to peo ple with nor mal BMD. More over, pa - tients with low bone min eral den sity had worse dy nam ics of SYSADOA treat ment