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dc.contributor.authorRossokha, Z.-
dc.contributor.authorFishchuk, L.-
dc.contributor.authorSheyko, L.-
dc.contributor.authorMedvedieva, N.-
dc.contributor.authorGorovenko, N.-
dc.date.accessioned2021-03-30T10:05:23Z-
dc.date.available2021-03-30T10:05:23Z-
dc.date.issued2020-
dc.identifier.issn1512-0112-
dc.identifier.urihttp://lib.inmeds.com.ua:8080/jspui/handle/lib/3371-
dc.description.abstractTreatment of hereditary hyperhomocysteinemia and the achievement of optimal folate status is necessary for persons of reproductive age in order to increase live birth rate. Patients are usually advised to take folic acid, a key nutrient in homocysteine remethylation. The results of study showed risk factors for hyperhomocysteinemia development in investigated married couples: male gender, MTHFR, MTR1 genes variants, lower vitamin B12 blood serum and no additional intake of vitamin B12. Since MTHFR, MTR1 genes variants affect to decrease the efficiency of homocysteine metabolic transformations, to contribute also to endothelial dysfunction in one of patients group we used betargine combined with folic acids and vitamin B12 administration. Patients group with combined administration including betargine within 2 weeks, in comparison with the group without its supplement, had significantly decreased level of homocysteine in plasma, less than 12 μmol/l (81.03% and 50% of cases, respectively). Folic acid and vitamin B12 mean values in blood serum was significantly increased in patients after two week vitamins administration including betargin. Further research is needed to establish the duration of betaine-arginine intake until the target homocysteine level will be reached, as well as to estimate the durability of clinical effect achieved after consumption.uk_UK
dc.language.isoenuk_UK
dc.publisherGeorgian Medical Newsuk_UK
dc.relation.ispartofseries309;c. 22-28-
dc.subjectmarried couplesuk_UK
dc.subjecthyperhomocysteinemiauk_UK
dc.subjectreproductive disorderuk_UK
dc.subjecttreatmentuk_UK
dc.subjectbetarginuk_UK
dc.titlePOSITIVE EFFECT OF BETAINE-ARGININE SUPPLEMENT ON IMPROVED HYPERHOMOCYSTEINEMIA TREATMENT IN MARRIED COUPLES WITH REPRODUCTIVE DISORDERS.uk_UK
dc.title.alternativeЭФФЕКТИВНОСТЬ БЕТАИН-АРГИНИН СОДЕРЖАЩЕЙ ДОБАВКИ В ЛЕЧЕНИИ ГИПЕРГОМОЦИСТЕИНЕМИИ В СУПРУЖЕСКИХ ПАРАХ С РЕПРОДУКТИВНЫМИ НАРУШЕНИЯМИuk_UK
dc.typeArticleuk_UK
Розташовується у зібраннях:Кафедра медичної та лабораторної генетики

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