Респіраторна, аутоімунна та нефрологічна коморбідність у хворих на розсіяний склероз: поширеність та особливості впливу на перебіг захворювання

Abstract

Introduction. For multiple sclerosis (MS) is characterized by not only a large number of neurological symptoms, due to numerous foci of demyelination, but also a close connection with the terms of comorbid pathology (CP), including respiratory diseases (RD), nephrological disorders (ND) and other autoimmune diseases (AID). Aim. To determine the prevalence of respiratory, nephrological and autoimmune disorders as manifestations of comorbidity in patients with MS, as well as the capabilities and features of its influence on the course of MS. Material and methods. The study involved 195 MS patients with different forms of motion. Evaluated the clinical and demographic characteristics of patients with MS in connection with comorbidity, determined the level of EDSS, fatigue severity for FSS and SАC. Results. Among the group of patients with comorbidities, the presence of RD was found in 37 (38.6%) patients, AID - in 10 (10.4%) patients, ND - in 15 (10.4%) patients. The level of disability on the EDSS group IIa (RD) and IIc (ND) was significantly higher than in group I (MS without CP), with the highest prevalence of neurological deficit in the group IIc; as group IIa and IIc were expressed significantly deeper fatigue manifestation according to the scale FSS and SAC. Conclusions. The combination of MS and other AID, more common in young women, while there is relatively mild, remitting course of MS. The combination of MS and ND, is more common in men, and the maximum expression observed symptoms of fatigue. For the combination of the MS and ND inherent in older age, longer duration of illness and the most severe manifestations of disability.