Characteristics of Primary Donors of Blood, According to the Results of Complex Laboratory, Morphologic, Biophysical and Biochemical Tests of Peripheral Blood

Abstract

Introduction. In spite of the increasing number of scientific research programs on the storage of donor blood, the integrated solution of this problem remains a challenging open issue. Purpose. To study laboratory, morphologic, biochemical and biophysical properties of donor blood erythrocytes, determine the pathogenesis of abnormalities in the erythrocytes of blood donors in order to increase effectiveness of early diagnostics and prevention of the above-mentioned changes for protection of donors’ health. Materials and methods. The study included 160 primary donors (83 men and 77 women) donating for the first time. The following methods were used: general blood tests, blood chemistry, radioimmune and enzyme-immunoassay, statistic methods. Results. The results of the performed laboratory, morphologic, biochemical and biophysical tests were the following: determination of erythrocyte index, reticulocyte count, red blood cell distribution, optical transmission of erythrocytes, test for aggregation and penetrability of erythrocyte membranes, effectiveness of erythropoiesis in erythrocytes of primary donors. They indicated that the donors of the control group are practically healthy people, whose test results are within the normal limits for their age group. Conclusions. In order to preserve health of donors and ensure the quality of blood components received at the time of donation, it is highly recommended to conduct before donation a complex examination of donors, including (in addition to the main and biochemical parameters of peripheral venous blood) the morphologic, biophysical and rheological parameters of erythrocytes.