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Поле DCЗначенняМова
dc.contributor.authorГармаш, О.В.-
dc.contributor.authorРоссоха, З.І.-
dc.contributor.authorГоровенко, Н.Г.-
dc.date.accessioned2020-11-05T14:31:00Z-
dc.date.available2020-11-05T14:31:00Z-
dc.date.issued2020-
dc.identifier.citationDOI: 10.36740/WLek202002126uk_UK
dc.identifier.issn0043-5147-
dc.identifier.urihttp://lib.inmeds.com.ua:8080/jspui/handle/lib/2233-
dc.description.abstractThe aim: The article deals with analyzing the influence of polymorphic variants of CYP19A1 [rs2414096, rs936306], ESR1 [rs2234693, rs9340799], IL1 [rs1143627], IL6 [rs1800796], IL10 [rs1800896] and RANKL [rs959389] genes on deciduous tooth eruption terms in individuals born macrosomic. Materials and methods: 171 individuals participated in the multi-stage study (144 macosomic-at-birth individuals and 27 normosomic-at-birth persons). This study included only persons who have preserved information about the timing of deciduous tooth eruption – 159 persons (aged from 4 to 55 years), male and female (male / female ratio was 1.5 / 1). Results and conclusions: The presence of the G allele in CYP19A1 [rs2414096] gene and the -351 A allele in ESR1 [rs9340799] gene were found to be risk factors for fetal macrosomia formation. The research revealed an association of RANKL [rs9594759] gene variants which is a multiplicative model of inheritance and IL-10 [rs1800896], an overdominant model of inheritance, with an increased risk of tooth delay. Besides the variants of RANKL [rs9594759] and IL-10 [rs1800896] genes a multidirectional modifying effect on the timing of tooth eruption in macrosomic-at-birth individuals made the variant of CYP19A1 [rs2414096] gene – a significant dominant and over-dominant model of inheritance. Further analysis of intergenic interactions will facilitate the application of the obtained results in clinical practice by creating a molecular profile of individuals with deviations in the tooth eruption timing.uk_UK
dc.language.isoenuk_UK
dc.publisherWiadomości Lekarskieuk_UK
dc.relation.ispartofseries73(2);342-351-
dc.subjectfetal macrosomiauk_UK
dc.subjectdeciduous teethuk_UK
dc.subjectCYP19A1 [rs2414096] genes polymorphismuk_UK
dc.subjectESR1 [rs9340799] genes polymorphismuk_UK
dc.subjectIL-10 [rs1800896] genes polymorphismuk_UK
dc.subjectRANKL:C>T [rs9594759] genes polymorphismuk_UK
dc.titleASSOCIATION BETWEEN RANKL [RS9594759] AND IL10 [RS1800896] GENES POLYMORPHISM AND DECIDUOUS TOOTH ERUPTION TERMS IN UKRAINIANS BORN MACROSOMICuk_UK
dc.typeArticleuk_UK
Розташовується у зібраннях:Кафедра медичної та лабораторної генетики



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