RETINAL VEIN OCCLUSION AFTER CARDIOSURGERY USING ARTIFICIAL BLOOD CIRCULATION AND MARKERS OF ACUTE INFLAMMATION AND ENDOTHELIAL DYSFUNCTION

Abstract

Cardiac surgery, accompanied by artificial circulation (AC) may be accompanied by perioperative complications on the part of the visual organ, which are related to retinal ischemia and development of ischemic optical neuropathy and retinal vein occlusions [1, 2]. When using AC, inflammation and endothelial dysfunction (EDF) are activated during the surgery, what leads to damage of internal organs [3]. The application of AC increases the penetrance of the microcirculation vessels of lungs, neutrophilous emigration, the content of IL-6 and other inflammatory markers, including, - a protein of cell-cell adhesion of vasculoendothelial cadherin (VE-C) [4,5]. The patients after AC had a content increase in the blood of VE-C [6], wich can be considered as the marker of EDF, as it regulates the connection of endothelial adhesives and vascular permeability [7-9]. Thus, acute inflammation and EDF can be considered as typical pathological processes that determine the development of RVO during cardiac surgery and the use of AC, but the relationship of serum markers in terms of occlusion remains unclear. The aim of the study was to investigate the possible relationship between retinal vein occlusions after cardiac surgery using artificial blood circulation and markers of acute inflammation and endothelial dysfunction.