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Назва: Pharmacogenetics of anesthesiological support
Автори: Скавінська, О.О.
Фіщук, Л.Є.
Чернявська, Ю.І.
Похилько, В.І.
Євсеєнкова, О.Г.
Ключові слова: Pharmacogenetics
Anesthetic Support
Inhalation Anesthetics
Neuromuscular Blockers
Propofol
General Anesthesia in Children
Opiates
Дата публікації: 2024
Видавництво: НЕОНАТОЛОГІЯ, ХІРУРГІЯ ТА ПЕРИНАТАЛЬНА МЕДИЦИНА / NEONATOLOGY, SURGERY AND PERINATAL MEDICINE
Бібліографічний опис: https://doi.org/10.24061/2413-4260.XIV.1.51.2024.19
Серія/номер: Т. 14, №1 (51);С. 131–140.
Короткий огляд (реферат): Genes are known to infl uence the pharmacokinetics and pharmacodynamics of the drug administered. The same dose of a drug may not be suffi cient for some patients and may be life-threatening or cause adverse side eff ects for others. Today, information about genetic factors is used by clinicians to prescribe drugs in order to tailor drug therapy to the patient’s genome. In anesthesiology, the principles of pharmacogenetics have been explained for neuromuscular blockers, opioid metabolism, diff erent types of anesthetics, and postoperative nausea and vomiting. This review discusses the pharmacogenomics of inhaled and topical anesthetics, opioids, and neuromuscular blocking agents currently used worldwide with a focus on the pediatric population.
Опис: Although pharmacogenomics is a relatively young fi eld, it has already been shown that a better understanding of an individual’s genome can improve drug therapy outcomes. The selection of drugs and dosing regimens based on a patient’s pharmacogenomic profi le may be an important part of the future of medicine. Personalized treatment based on the specifi c variant(s) in the genome will ultimately reduce the incidence of side eff ects and length of hospital stay for patients and save healthcare costs [60, 61]. Although pharmacogenomics and its application in clinical practice are still in their infancy, diff erent variants and their implications for many clinical areas, including anesthesiology, are emerging daily. However, the evidence in most pharmacogenetic studies is still inconclusive, and more large- scale prospective studies are needed.
URI (Уніфікований ідентифікатор ресурсу): http://lib.inmeds.com.ua:8080/jspui/handle/lib/4978
ISSN: ISSN 2413-4260 (Online), ISSN 2226-1230 (Print)
Розташовується у зібраннях:Кафедра медичної та лабораторної генетики

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