Reproductive disorders in patients with Metabolic Syndrome and Obesity: Pathogenesis, Clinical Manifestations and Prevention

Abstract

The issues of pathogenesis, clinical manifestations, outcomes and prevention of reproductive disorders and infertility in patients with metabolic syndrome (MetS) and obesity studied. It was found that the main reproductive disorders of men with MetS were decreased testosterone levels, decreased sperm fertility and erectile dysfunction. In women with MetS, metabolic disorders also lead to reproductive disorders such as infertility, menstrual irregularities, premature birth, births of children with congenital anomalies. Reproductive disorders in patients with MetS can have negative consequences for individuals as reduced quality of life, depression and increasing metabolic disorders, and for the countries as depopulation. Normalization of basal metabolic rate by exercise and a diet improves reproductive health in patients with MetS. However, despite the proven positive impact of lifestyle adjustment, the search for the best cures’ treatment for reproductive disorders of patients with MetS remains open.