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Назва: Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group
Автори: Gil Amarilyo
Deborah Rothman
Kalpana Manthiram
Suzanne C Li
Kathryn M Edwards
Gary S Marshall
Cagri Yildirim-Toruner
Kathleen Haines
Polly J Ferguson
Geraldina Lionetti
Julie Cherian
Yongdong Zhao
Patricia DeLaMora
Grant Syverson
Simona Nativ
Marinka Twilt
Ian C Michelow
Yuriy Stepanovskiy
Akaluck Thatayatikom
Liora Harel
Shoghik Akoghlanian
Lori Tucker
Mariana Correia Marques
Hemalatha Srinivasalu
Evan J Propst
Greg R Licameli
Fatma Dedeoglu
Sivia Lapidus
Ключові слова: PFAPA
Periodic fever
Recurrent fever
Consensus treatment plan
Дата публікації: 15-кві-2020
Видавництво: Springer Nature
Бібліографічний опис: Amarilyo, G., Rothman, D., Manthiram, K., Edwards, K. M., Li, S. C., Marshall, G. S., Yildirim-Toruner, C., Haines, K., Ferguson, P. J., Lionetti, G., Cherian, J., Zhao, Y., DeLaMora, P., Syverson, G., Nativ, S., Twilt, M., Michelow, I. C., Stepanovskiy, Y., Thatayatikom, A., Harel, L., … CARRA PFAPA Consensus Treatment Plan Workgroup (2020). Consensus treatment plans for periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA): a framework to evaluate treatment responses from the childhood arthritis and rheumatology research alliance (CARRA) PFAPA work group. Pediatric rheumatology online journal, 18(1), 31. https://doi.org/10.1186/s12969-020-00424-x
Короткий огляд (реферат): Background Periodic fever, aphthous stomatitis, pharyngitis, and cervical adenitis (PFAPA) syndrome is the most common periodic fever syndrome in children. There is considerable heterogeneity in management strategies and a lack of evidence-based treatment guidelines. Consensus treatment plans (CTPs) are standardized treatment regimens that are derived based upon best available evidence and current treatment practices that are a way to enable comparative effectiveness studies to identify optimal therapy and are less costly to execute than randomized, double blind placebo controlled trials. The purpose of this project was to develop CTPs and response criteria for PFAPA. Methods The CARRA PFAPA Working Group is composed of pediatric rheumatologists, infectious disease specialists, allergists/immunologists and otolaryngologists. An extensive literature review was conducted followed by a survey to assess physician practice patterns. This was followed by virtual and in-person meetings between 2014 and 2018. Nominal group technique (NGT) was employed to develop CTPs, as well as inclusion criteria for entry into future treatment studies, and response criteria. Consensus required 80% agreement. Results The PFAPA working group developed CTPs resulting in 4 different treatment arms: 1. Antipyretic, 2. Abortive (corticosteroids), 3. Prophylaxis (colchicine or cimetidine) and 4. Surgical (tonsillectomy). Consensus was obtained among CARRA members for those defining patient characteristics who qualify for participation in the CTP PFAPA study. Conclusion The goal is for the CTPs developed by our group to lead to future comparative effectiveness studies that will generate evidence-driven therapeutic guidelines for this periodic inflammatory disease.
URI (Уніфікований ідентифікатор ресурсу): http://lib.inmeds.com.ua:8080/jspui/handle/lib/3363
Розташовується у зібраннях:Кафедра дитячих інфекційних хвороб та дитячої імунології

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