Вплив симптомів дебюту на перебіг розсіяного склерозу в аспекті коморбідності

Abstract

Despite the long1term study of multiple sclerosis (MS) and the suc1 cesses achieved, an increase in the prevalence of MS in the world shows that many of the issues of this pathology have not been com1 pletely solved: first of all, it concerns the risk factors, pathogenesis, the effectiveness of treatment and rehabilitation approaches. The objective: to analyze the symptoms of MS patients debut and their prognostic value on the course of the disease in the aspect of comorbidity. Materials and methods. Anamnestic data of 216 MS patients were analyzed for neurologic disorders at the onset of the disease; distribu1 tion of patients depending on the month of birth (MH) and depending on the season and month of MS debut. Results. An analysis of neurologic disorders at the onset of the disease was performed: in 171 (79,2%) patients, the PC debut was mono1 symptomatic, and in 45 (20,8%) patients multifocal symptoms were identified as the first manifestations of the disease. Conclusions. In the PC debut, the most frequent sign of the progres1 sive course was motor (26,1%), sensitive (14,3%) and oculomotor (9,1%) violations; The signs of remission were visual disturbances (23,0%) and polysymptomatic disorders (18,0%).