The relationship between obesity and vitamin D levels in postmenopausal women

Abstract

Insufficiency and deficiency of vitamin D is global problem of the 21st century. No less urgent a question of overweight and obesity all over the world. According to the literature review patients with obesity have lower level of vitamin D. This two seemingly insignificant factors in fact increased risk of dozens diseases and should be controlled. In the Department of Clinical Physiology and Pathology of the musculoskeletal system, State Institution "Institute of Gerontology NAMS Ukraine" were observed 1007 women, 50-89 years old (the mean age is 65.74±8.61 years old). Patients were detected 25-hydroxyvitamin D level, weight, height and on body mass index (BMI). Aim: to observe the level of 25-hydroxyvitamin D depending on body mass index (BMI) in postmenopausal women. Materials and methods: in accordance with their BMI all women were divided into 6 groups. I group consisted of 338 women with normal body weight. In II group were 16 women with insufficient body weight. III group formed 382 women with excessive weight. Next two groups IV and V were 199 women with class I obesity and 60 women with class II obesity and in VI group were 12 women with class III obesity. Serum level of 25(OH)D was tested by electrochemiluminescent method - Elecsys 2010 analyzer (Roche Diagnostics, Germany) and cobas test system.

Results: 34.4% of the examined women have deficiency and 31.4% insufficiency of vitamin D. Significantly lower level of 25 (OH) D had females with class I obesity - 23.60±10.24 ng/ml and class II obesity - 22.38±10.34 ng/ml compared to women with normal body weight - 28.24±12.99 ng/ml (p=0.00003). In women with obesity, BMI has significantly impact on vitamin D level, but does not depend on the season.