Будь ласка, використовуйте цей ідентифікатор, щоб цитувати або посилатися на цей матеріал: http://lib.inmeds.com.ua:8080/jspui/handle/lib/1821
Назва: ESR1 GENE RELATED RISK IN THE DEVELOPMENT OF IDIOPATHIC INFERTILITY AND EARLY PREGNANCY LOSS IN MARRIED COUPLES
Інші назви: ESR1 ОБУСЛОВЛЕННЫЙ ГЕНЕТИЧЕСКИЙ РИСК РАЗВИТИЯ ИДИОПАТИЧЕСКОГО БЕСПЛОДИЯ И РАННИХ РЕПРОДУКТИВНЫХ ПОТЕРЬ В СУПРУЖЕСКИХ ПАРАХ
Автори: Фіщук, Л.Є.
Россоха, З.І.
Шейко, Л.П.
Брішевац, Л.І.
Горовенко, Н.Г.
Ключові слова: married couples
early reproductive losses
idiopathic infertility
ESR1
gene
Дата публікації: 2020
Видавництво: Georgian Medical News
Серія/номер: No 6 (303);
Короткий огляд (реферат): The aim of the work was to assess genetic risk of reproductive disorders in married couples, conditioned by polymorphic variants A-351G and T-397C of ESR1gene. The study involved 412 persons – 206 married couples: 69 married couples with idiopathic infertility, lasting over 5 years, and 137 married couples with early reproductive losses in their past medical history. The data of population frequencies for the European population, obtained from the open database of 1000 Genomes project, were used as a comparison group. The polymorphic variants A-351G and T-397C of ESR1 gene were investigated using the method of polymerase chain reaction with subsequent analysis of the restriction fragment length polymorphisms. It was determined that the presence of genetic variant -351GG (log-additive model of inheritance) and the combination of genotypes -351GG/-397CC of ESR1 gene was associated with the increasing risk of developing male idiopathic infertility. The association of the polymorphic variant A-351G of ESR1 gene with the increasing risk of developing idiopathic infertility (logadditive model of inheritance) and early reproductive losses (over-dominant model of inheritance) was revealed in women from the examined married couples. Significant protective effects in terms of reproductive disorders in men were found for the combinations of genotypes -351AA/-397TT and -351AA/-397TC of ESR1 gene. The obtained results demonstrated new view about the ESR1 identical genetic mechanisms of developing idiopathic infertility and early pregnancy loss in couples. These determined specificities highlight the need of conducting genetic investigations of both ESR1 polymorphic variants in couples and the significance of searching for phenotypic manifestations of investigated reproductive disorders which occurred due to genetic variants.
URI (Уніфікований ідентифікатор ресурсу): http://lib.inmeds.com.ua:8080/jspui/handle/lib/1821
ISSN: 1512-0112
Розташовується у зібраннях:Кафедра медичної та лабораторної генетики

Файли цього матеріалу:
Файл Опис РозмірФормат 
ESR1 GENE RELATED RISK IN THE DEVELOPMENT OF IDIOPATHIC INFERTILITY AND EARLY PREGNANCY LOSS IN MARRIED COUPLES.pdf1.13 MBAdobe PDFПереглянути/Відкрити


Усі матеріали в архіві електронних ресурсів захищені авторським правом, всі права збережені.