http://localhost:8080/handle/lib/206 Sat, 10 Oct 2026 05:36:29 GMT 2026-10-10T05:36:29Z http://localhost:8080/handle/lib/3837 Title: «Постковідний синдром»: неврологічні прояви та лікування українським препаратом Когнум Authors: Новікова, Ольга Володимирівна Abstract: У статті розглянуті особливості вірусних уражень під час пандемії COVID-19 та патогенетичне обґрунтування призначення препарату Когнум у лікуванні неврологічних ускладнень після перенесеного захворювання. Fri, 01 Jan 2021 00:00:00 GMT http://localhost:8080/handle/lib/3837 2021-01-01T00:00:00Z http://localhost:8080/handle/lib/3836 Title: Renal, Hepatic and Immune Function Indicies in Patients with Duchenne Muscular Dystrophy Authors: Кононець, Оксана Миколаївна; Караєв, Тимур Вагифович; Ткаченко, Олена Василівна; Лічман, Лада Юріївна Abstract: The purpose of the study is to examine in depth and analyze renal, hepatic and immune function indices in patients with Duchenne muscular dystrophy. We analyzed the follow up clinical and laboratory data of Duchenne muscular dystrophy in 32 patients. The patients underwent a standardized examination, involving studying the medical case history, general clinical data, determining Sheldon's somatotype and the constitutional type, the detailed neurological status examination, testing a personality type, laboratory and instrumental examinations. Through the laboratory examination we determined the general blood test indicators, total serum protein levels, total cholesterol, the ALAT, ASAT, CPK levels, creatinine and urea blood levels, glomerular filtration rate (GFR), the immunogram indices (dynamic data (B-lymphocytes (CD19/CD45), %; T-lymphocytes (CD3/CD 45), %; T-helpers (CD3/CD45/CD4), %; T-suppressors (CD3/CD45/ CD8), %; CD4:CD8 ratio; natural killer cells ratio, myositis profile (Mi-2, IgG antibodies (idiopathic myositis marker); Ku, IgG antibodies (sclerodermia and myositis combination marker); the PM-Scl complex, IgG antibodies (sclerodermia marker); histidyl tRNA synthetase (Jo-1), IgG antibodies; threonyl-tRNA synthetase (PL-7), IgG antibodies; alanyl-tRNA synthetase (PL-12), IgG antibodies; RING-type E3 ubiquitin-ligase (Ro-52), IgG antibodies and the genetic markers of the disease. The instrumental examination included the ultrasound of the abdominal organs, muscles, as well as echo-cardiography, electroneuromyography. According to the analysis of the immunograms, the T-helpers level was found to be below the reference value in 14 patients (45,2%). Herewith, the B-lymphocytes count was observed to deviate from the norm in only 4 patients (8%). However, there was established the presence of an indirect moderate correlation between the B-lymphocytes count and Creatine phosphokinase level in patients with Duchenne muscular dystrophy; the correlation coefficient was equal to - 0.42 (р<0,05). Having analyzed the renal function indices, we revealed that the creatinine blood level was lower than the lower limit of the reference values in almost a third of patients (21%), but the glomerular filtration rate (GFR) by the SKD-EPI formula was found to be insignificantly reduced in 16% of patients, and it was within 66-87 ml/min/1.73 m2. Regardless, no correlation between the Creatine phosphokinase level, on one side, and creatinine blood level and the glomerular filtration rate, on the other side, was found. However, there was established the presence of an indirect weak correlation between the Creatine phosphokinase level and serum urea level in patients with Duchenne muscular dystrophy (the correlation coefficient was equal to - 0.28, p<0.05). Having analyzed the hepatic function indices, we revealed that such indicators of liver enzymatic activity as alanine aminotransferase and aspartate aminotransferase were significantly over the limit in almost all the patients (94%) with Duchenne muscular dystrophy. Concurrently, we revealed the presence of a direct strong correlation between the Creatine phosphokinase level and the alanine aminotransferase level, which was equal to +0,86 (р<0,05) and the presence of a direct moderate correlation between the aspartate aminotransferase and the Creatine phosphokinase level which was equal to + 0.56 (р<0,05). We also found that the level of alkaline phosphatase was also significantly higher than the normal one in 69% of our patients. The patients with Duchenne muscular dystrophy had various multidirectional disorders of the immune status, impaired renal function (in particular, a decrease in serum creatinine concentration and reduced glomerular filtration rate), as well as the divergence of liver enzyme parameters (in particular, a significant increase in transaminase levels). Tue, 01 Dec 2020 00:00:00 GMT http://localhost:8080/handle/lib/3836 2020-12-01T00:00:00Z http://localhost:8080/handle/lib/3834 Title: Cerebral Hemispheres – Cerebellum – Kidney Interaction in Patients with Acute Cerebral Ischemia Authors: Кононець, Оксана Миколаївна; Ткаченко, Олена Василівна; Каменецька, Оксана Олегівна Abstract: The nervous system, in particular the autonomic one, is well known to constantly regulate the internal functioning of the body, adapting it to changeable external and internal environmental parameters. In particular, there is a close multiple-vector correlation between the nervous system and the kidneys. The aim of this study was to specify the mechanisms, clinical and paraclinical characteristics of the concomitant lesions of the nervous system and the kidneys in patients with acute stroke. This paper presents the case report of 215 patients, aged 70 ± 8.44, who suffered from ischemic stroke. Among them, we examined 144 women and 71 men. The patients underwent a comprehensive examination, including a detailed clinical and neurological check-up (evaluating the patients’ condition severity with the National Institutes of Health Stroke Scale (NIHSS) and the Barthel index on admission and on the 21st day of the disease), laboratory analysis (electrolyte balance, nitrogen metabolism (on admission and on the 21st day of the disease) and instrumental examination (CT scan of the brain, the follow-up brain magnetic resonance imaging). The statistical methods were used to analyze the data. In the 1st day of the disease, all the surveyed patients with right hemispheric carotid stroke and the overwhelming majority of the patients with left hemispheric carotid stroke and ischemic stroke in the vertebrobasilar system had cerebral renal syndrome, represented by renal concentration-filtration dysfunction, accompanied by the reduced glomerular filtration rate. A reliable relationship was found between the renal concentration and filtration function and the right hemispheric ischemic focus in patients with ischemic stroke, the characteristics are to be specified. Fri, 26 Mar 2021 00:00:00 GMT http://localhost:8080/handle/lib/3834 2021-03-26T00:00:00Z http://localhost:8080/handle/lib/2277 Title: Mechanisms of Toxic Effects of Homocysteine on the Nervous System Authors: Невмержицька, Наталія Миколаївна; Оржешковьский, Василь Володимирович; Дзевульська, Ірина Вікторівна; Савосько, Сергій Іванович Abstract: The role of homocysteine in neurochemical and neurophysiological processes in mammalians, including humans, is difficult to overestimate. The metabolism of homocysteine is mostly based on its re-methylation and trans-sulfonation occurring at sufficient levels of vitamins B6, B12, and that of folic acid (vitamin B9). The balance between the above-mentioned processes crucially determines the level of homocysteine in the organism. The effects of this compound on nerve tissues in the case of its excessive amount may be due to direct neurotoxic effects or are mediated by vascular mechanisms. Homocysteine affects many physiological processes in the human organism. A high level of homocysteine causes a direct cytotoxic effect on the endothelium, which simultaneously increases the consumption of nitric oxide and initiates the release of cytokines, cyclins, and other mediators of inflammation. Also, it causes excessive proliferation of smooth muscle cells of the vascular wall and of endotheliocytes, acts as a procoagulant, increases the concentrations of low-density and very-low-density lipoproteins, and reduces the production of endothelium-derived relaxing factor and sulfated glycosaminoglycans. Thus, the role of hyperhomocysteinemia in pathological events in the vascular system is twofold. First, it damages the endothelium, which is associated with early atherogenesis, and second, it increases the probability of development of thrombosis in veins and arteries, including cerebral ones. Sun, 01 Sep 2019 00:00:00 GMT http://localhost:8080/handle/lib/2277 2019-09-01T00:00:00Z